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Thursday, July 16, 2020 | History

4 edition of Transformation and translocation of the human aromatic hydrocarbon receptor found in the catalog.

Transformation and translocation of the human aromatic hydrocarbon receptor

Transformation and translocation of the human aromatic hydrocarbon receptor

a comparison of 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

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Published by National Library of Canada = Bibliothèque nationale du Canada in Ottawa .
Written in English


Edition Notes

SeriesCanadian theses = Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches.
ID Numbers
Open LibraryOL18791383M
ISBN 100612287998
OCLC/WorldCa46575528

Toxic equivalency factors (TEFs) of 31 non-substituted polycyclic aromatic hydrocarbons (PAHs) for the human aryl hydrocarbon receptor (AhR) ligand activity were measured using the yeast recombinant reporter gene assay established by Miller et al., in order to estimate the toxic equivalents of individual PAHs in environmental PAHs showed sigmoid-shape Cited by: @article{osti_, title = {Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB in human skin and liver-derived cell lines}, author = {Vorrink, Sabine U. and Department of Radiation Oncology, The University of Iowa, Iowa City, IA and Severson, Paul L. and Kulak, Mikhail V. and Futscher, Bernard W.

Results: Poly aromatic hydrocarbons increase heme synthesis in liver by activating ABCB6 expression via the aryl hydrocarbon receptor Conclusion: ABCB6 is required for PAH mediated induction of heme biosynthesis Significance: ABCB6 expression might be clinically relevant in poly aromatic hydrocarbon induced porphyrias and carcinogenesis. ARYL HYDROCARBON RECEPTOR LIGANDS. Richard J. Wall, BSc. MRes. HAH Halogenated aromatic hydrocarbon HepG2 Human hepatocellular carcinoma cell line Hepa1c1c7 Mouse hepatoma cell line Hsp90 90 kDa Heat shock protein IC PAH Polycyclic Aromatic Hydrocarbon PAS Per, Arnt, AhR, Sim.

The aim of this study is to show the effects of activating aryl hydrocarbon receptor (AhR) by specific ligands, on the expression of responsive genes. Specific AhR-ligands were reported to play an important role in immune regulation. This chapter will focus mostly on the effects of activating AhR with different ligands on autoimmunity. Findings showed the possibility of using Author: Hana’a Burezq.   Background: ABCB6 is an ATP binding cassette transporter that regulates heme biosynthesis. Results: Polyaromatic hydrocarbons increase heme synthesis in liver by activating ABCB6 expression via the aryl hydrocarbon receptor. Conclusion: ABCB6 is required for PAH-mediated induction of heme biosynthesis. Significance: ABCB6 expression might be clinically .


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Transformation and translocation of the human aromatic hydrocarbon receptor Download PDF EPUB FB2

Transformation and Truislcmtion of the Human Aromatic Hydrocarbon Receptor: A Cornpuison of 3-Methylcholanthrene and 2,3,7,8=Tetrachlorodibenzo+ioràn Mary A. Holowenko, M. Department of Phannacology University of Toronto.

The aromatic hydrocarbon receptor (AHR), upon binding ligand, dimerizes with the AH receptor nuclear translocator protein Author: Mary A. Holowenko. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor.

Nature– (). [Google Scholar] Jin U. et al. Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities. Mol Pharma – (). [PMC free article] [Google Scholar]Cited by: Aromatic Hydrocarbon Receptor. Aryl hydrocarbon receptor (AhR) is a dependent ligand transcription factor, which can sometimes promote polarization of Treg (Quintana et al., ), sometimes that of Th17 (Quintana et al., ).

From: International Review of Cell and Molecular Biology, Related terms: Polychlorinated Biphenyl. Unlabelled: Transformation of an aryl hydrocarbon receptor (AhR) is the initial step to express the multiple toxicity of halogenated and polycyclic aromatic hydrocarbons (HAHs and PAHs) including.

The ligand-activated aromatic hydrocarbon receptor (AHR) dimerizes with the AHR nuclear translocator (ARNT) to form a functional complex that transactivates expression of the cytochrome P CYP1A1 gene and other genes in the dioxin-inducible [Ah] gene us work from this laboratory has shown that the activity of the CYP1A1 enzyme negatively regulates this Cited by:   Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, which facilitate Cited by:   Abstract.

Aryl hydrocarbon receptor (AHR) and its heterodimer aryl hydrocarbon nuclear translocator (ARNT) form a ligand-activated transcription complex that regulates expression of the AHR battery of target genes that includes the most important placental biotransformation enzyme cytochrome by: Per-Arnt-Sim family of transcription factors.

AhR is a xenobiotic-sensing receptor responsible for the adverse toxicologic effects elicited by various polycyclic aromatic hydrocarbon environmental and industrial pollutants, perhaps the most infamous being 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

The basic mechanism of action of dioxin and. Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PubMed, PubMed, PubMed, PubMed, PubMed). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed).

Mediates. An endogenous ligand of the human aryl hydrocarbon receptor promotes tumor formation. Christiane A. Opitz 1,2*, Ulrike M. Litzenburger 1,2*, Felix Sahm 3, Martina Ott 1,2, Isabel.

Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) or Brain and Muscle ARNT-Like 1 (BMAL1) is a protein that in humans is encoded by the Bmal1 gene, also known as ARNTL, MOP3, and, less commonly, BHLHE5, BMAL, BMAL1C, JAP3, PASD3, and TIC. BMAL1 encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS human Aliases: ARNTL, BMAL1, BMAL1c, JAP3.

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological and toxicological effects of an AhR lacking the entire PASB structurally diverse chemicals, including halogenated aromatic hydrocarbons.

Ligand-dependent transformation of the AhR into its DNA binding form involves a ligand-dependent conformational change, heat shock. The aryl hydrocarbon receptor (AHR) is a ligand-activated basic helix-loop-helix Per-Arnt-Sim protein transcription factor (Okey et al., ; Poland and Knutson, ; Poland et al., ; Swanson and Bradfield, ).The AHR can be activated by a diverse array of compounds including planar polycyclic aromatic hydrocarbons (PAHs) such as Cited by: 1.

Introduction. The aromatic hydrocarbon receptor (AHR) and AHR nuclear translocator protein (ARNT) mediate the toxic effects of a wide variety of halogenated and polycyclic aromatic hydrocarbons, the most potent of which are the dioxins.The AHR resides in the cytoplasm of target cells associated with two kD heat shock proteins until activated by ligand, at which Cited by: Aryl Hydrocarbon Receptor Is a Transcriptional Activator of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) S Kah Poh Tan, Bernice Wang, Mingdong Yang, Paul C.

Boutros, Jane MacAulay, Haibo Xu, Andrew I. Chuang, Kazuhiro Kosuge, Mika Yamamoto, Shinichiro Takahashi, Alex M. Wu, Douglas D. Ross, Patricia A. Harper, and Shinya ItoFile Size: 1MB. Estrogen receptor and aromatic hydrocarbon receptor in the primate ovary In addition, no data exist that localize the aromatic hydrocarbon (dioxin) receptor (AHR), which is known to modulate ER, to the primate ovary.

H., Suginami, H., Liao, S., and Mori, T. Immunocytochemical localization of androgen receptor in the human ovary Cited by: This is a Validated Antibody Database (VAD) review about human aryl hydrocarbon receptor, based on 12 published articles (read how Labome selects the articles), using aryl hydrocarbon receptor antibody in all is aimed to help Labome visitors find the most suited aryl hydrocarbon receptor antibody.

Ensembl ENSG ENSMUSG UniProt Q9NZN9 QK1 RefSeq (mRNA) NM_ NM_ NM_ NM_ NM_ NM_ NM_ NM_ NM_ RefSeq (protein) NP_ NP_ NP_ NP_ NP_ NP_ Aliases: AIPL1, AIPL2, LCA4, aryl. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically studied for its role in environmental chemical-mediated toxicity and carcinogenicity.

In the last 5 years, however, it has become clear that the AhR, presumably activated by endogenous ligand(s), plays an important role in immune system development and by: The Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression.

The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or polycyclic aromatic hydrocarbons which are widespread environmental pollutant causing a variety of severe health effects, e.g.

immunosuppression, carcinogenesis and. SCETC REPORTS DOI: srep 1 entificreports Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles TroyD. Hubbard1,2, 2, William 3, Tejas S. Lahoti2, KrishneGowda4, Shantu G. Amin4, son2 & GaryH. Perdew2 Ligand activation of the aryl hydrocarbon .Here we demonstrate that the AhR activators induce CYP3A4 through human pregnane X receptor (PXR).

AhR activators, polycyclic aromatic hydrocarbons (PAHs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increased CYP3A4 reporter activity and CYP3A4 mRNA expression in HepG2 cells.

The CYP3A4 reporter activity was also increased by treatment with Cited by:   Breast cancer resistance protein (BCRP/ABCG2) is a membrane-bound efflux transporter important in cellular detoxification and multidrug resistance.

Some aryl hydrocarbon receptor (AHR) agonists were reported to induce BCRP expression in human colon carcinoma cells. However, a direct involvement of AHR transcriptional regulation remains by: